Background: Interleukin-17 (IL-17) is a cytokine pivotal in inflammation, autoimmune disorders, and cancer. This cytokine family comprises six members, including IL-17A to IL-17F, and five receptors, namely IL-17RA to IL-17RD and SEF. Several clinical studies have shown an increased expression of IL-17 in neoplastic disorders. Additionally, single nucleotide polymorphisms (SNPs) can impact gene functions and protein expression, which can in turn affect cellular proliferation and ultimately increase the risk of developing cancer. IL17F rs763780 gene polymorphism is linked to an increased risk of several malignancies and immunological disorders. The present study investigated the association between IL17F rs763780 gene polymorphism and susceptibility, clinicopathological features, and prognosis in adult Egyptian patients with AML. Patients and method: 102 AML patients (68 males and 34 females) and 106 healthy individuals were genotyped for the IL17F rs763780 gene using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay. Results: Homozygous mutant GG genotype and G allele were significantly higher in AML patients than in the healthy control. However, no significant correlation was found between the gene polymorphism and disease characteristics or prognosis in different genotypes. Conclusion: mutant genotypes and alleles of the IL17F rs763780 gene polymorphism may be associated with an increased risk of AML among Egyptian patients.
| Published in | Cancer Research Journal (Volume 12, Issue 1) |
| DOI | 10.11648/crj.20241201.13 |
| Page(s) | 10-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
AML, IL17F rs763780, Prognosis
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APA Style
Elderiny, W. E., Ebrahim, M. A., Ramez, A. M., Taalab, M. M. (2024). IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Research Journal, 12(1), 10-15. https://doi.org/10.11648/crj.20241201.13
ACS Style
Elderiny, W. E.; Ebrahim, M. A.; Ramez, A. M.; Taalab, M. M. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res. J. 2024, 12(1), 10-15. doi: 10.11648/crj.20241201.13
AMA Style
Elderiny WE, Ebrahim MA, Ramez AM, Taalab MM. IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia. Cancer Res J. 2024;12(1):10-15. doi: 10.11648/crj.20241201.13
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Download@article{10.11648/crj.20241201.13,
author = {Wesam Eldesouky Elderiny and Mohamed Awad Ebrahim and Ahmed Mohamed Ramez and Mona Mohamed Taalab},
title = {IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia},
journal = {Cancer Research Journal},
volume = {12},
number = {1},
pages = {10-15},
doi = {10.11648/crj.20241201.13},
url = {https://doi.org/10.11648/crj.20241201.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.crj.20241201.13},
abstract = {Background: Interleukin-17 (IL-17) is a cytokine pivotal in inflammation, autoimmune disorders, and cancer. This cytokine family comprises six members, including IL-17A to IL-17F, and five receptors, namely IL-17RA to IL-17RD and SEF. Several clinical studies have shown an increased expression of IL-17 in neoplastic disorders. Additionally, single nucleotide polymorphisms (SNPs) can impact gene functions and protein expression, which can in turn affect cellular proliferation and ultimately increase the risk of developing cancer. IL17F rs763780 gene polymorphism is linked to an increased risk of several malignancies and immunological disorders. The present study investigated the association between IL17F rs763780 gene polymorphism and susceptibility, clinicopathological features, and prognosis in adult Egyptian patients with AML. Patients and method: 102 AML patients (68 males and 34 females) and 106 healthy individuals were genotyped for the IL17F rs763780 gene using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay. Results: Homozygous mutant GG genotype and G allele were significantly higher in AML patients than in the healthy control. However, no significant correlation was found between the gene polymorphism and disease characteristics or prognosis in different genotypes. Conclusion: mutant genotypes and alleles of the IL17F rs763780 gene polymorphism may be associated with an increased risk of AML among Egyptian patients.
},
year = {2024}
}
TY - JOUR T1 - IL17F Gene Polymorphism in Egyptian Adult Patients with Acute Myeloid Leukemia AU - Wesam Eldesouky Elderiny AU - Mohamed Awad Ebrahim AU - Ahmed Mohamed Ramez AU - Mona Mohamed Taalab Y1 - 2024/02/05 PY - 2024 N1 - https://doi.org/10.11648/crj.20241201.13 DO - 10.11648/crj.20241201.13 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 10 EP - 15 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/crj.20241201.13 AB - Background: Interleukin-17 (IL-17) is a cytokine pivotal in inflammation, autoimmune disorders, and cancer. This cytokine family comprises six members, including IL-17A to IL-17F, and five receptors, namely IL-17RA to IL-17RD and SEF. Several clinical studies have shown an increased expression of IL-17 in neoplastic disorders. Additionally, single nucleotide polymorphisms (SNPs) can impact gene functions and protein expression, which can in turn affect cellular proliferation and ultimately increase the risk of developing cancer. IL17F rs763780 gene polymorphism is linked to an increased risk of several malignancies and immunological disorders. The present study investigated the association between IL17F rs763780 gene polymorphism and susceptibility, clinicopathological features, and prognosis in adult Egyptian patients with AML. Patients and method: 102 AML patients (68 males and 34 females) and 106 healthy individuals were genotyped for the IL17F rs763780 gene using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) assay. Results: Homozygous mutant GG genotype and G allele were significantly higher in AML patients than in the healthy control. However, no significant correlation was found between the gene polymorphism and disease characteristics or prognosis in different genotypes. Conclusion: mutant genotypes and alleles of the IL17F rs763780 gene polymorphism may be associated with an increased risk of AML among Egyptian patients. VL - 12 IS - 1 ER -
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Medical Oncology Department, Oncology Center Mansoura University, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Medical Oncology Department, Oncology Center Mansoura University, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Internal Medicine Department, Oncology Center Mansoura University, Faculty of Medicine, Mansoura University, Mansoura, Egypt
