Arsenic is an ubiquitous element in the environment. In the present study we investigated the effects of arsenic trioxide (AsIII) on lipid peroxidation and on the activity of antioxidant enzymes in the kidney of albino mice. Albino mice were divided into three groups. Group I were kept as control. Group II were administrated an oral dose of arsenic trioxide (3mg/kg b.w.). Group III were given an oral dose of arsenic trioxide (6mg/kg b.w.). They were acclimatized for 15 days before administration of arsenic trioxide. The autopsies were done from all the groups at 15 days post-treatment. Malondialdehyde (MDA) and activities of Superoxide dismutase (SOD) and Catalase (CAT) were analyzed in kidney of albino mice. The results showed a significant increase in concentration of MDA (p<0.05). Activities of SOD and CAT were found to decrease significantly (p<0.05). The results indicated that arsenic induced oxidative stress in albino mice by producing free radicals and lipid peroxidation where antioxidant enzymes were used as biomarkers.
| Published in |
American Journal of BioScience (Volume 4, Issue 3-1)
This article belongs to the Special Issue Recent Trends in Experimental Toxicology |
| DOI | 10.11648/j.ajbio.s.2016040301.11 |
| Page(s) | 1-4 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2016. Published by Science Publishing Group |
Arsenic, Malondialdehyde, Lipid Peroxidation, Oxidative Stress, CAT, SOD
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APA Style
Suman Sharma, Anjali Singh Gill, Zorawar Singh, Charanjit Kaur, P. Vijaya. (2016). Nephrotoxic Effects of Arsenic in Albino Mice. American Journal of BioScience, 4(3-1), 1-4. https://doi.org/10.11648/j.ajbio.s.2016040301.11
ACS Style
Suman Sharma; Anjali Singh Gill; Zorawar Singh; Charanjit Kaur; P. Vijaya. Nephrotoxic Effects of Arsenic in Albino Mice. Am. J. BioScience 2016, 4(3-1), 1-4. doi: 10.11648/j.ajbio.s.2016040301.11
AMA Style
Suman Sharma, Anjali Singh Gill, Zorawar Singh, Charanjit Kaur, P. Vijaya. Nephrotoxic Effects of Arsenic in Albino Mice. Am J BioScience. 2016;4(3-1):1-4. doi: 10.11648/j.ajbio.s.2016040301.11
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Download@article{10.11648/j.ajbio.s.2016040301.11,
author = {Suman Sharma and Anjali Singh Gill and Zorawar Singh and Charanjit Kaur and P. Vijaya},
title = {Nephrotoxic Effects of Arsenic in Albino Mice},
journal = {American Journal of BioScience},
volume = {4},
number = {3-1},
pages = {1-4},
doi = {10.11648/j.ajbio.s.2016040301.11},
url = {https://doi.org/10.11648/j.ajbio.s.2016040301.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.s.2016040301.11},
abstract = {Arsenic is an ubiquitous element in the environment. In the present study we investigated the effects of arsenic trioxide (AsIII) on lipid peroxidation and on the activity of antioxidant enzymes in the kidney of albino mice. Albino mice were divided into three groups. Group I were kept as control. Group II were administrated an oral dose of arsenic trioxide (3mg/kg b.w.). Group III were given an oral dose of arsenic trioxide (6mg/kg b.w.). They were acclimatized for 15 days before administration of arsenic trioxide. The autopsies were done from all the groups at 15 days post-treatment. Malondialdehyde (MDA) and activities of Superoxide dismutase (SOD) and Catalase (CAT) were analyzed in kidney of albino mice. The results showed a significant increase in concentration of MDA (p<0.05). Activities of SOD and CAT were found to decrease significantly (p<0.05). The results indicated that arsenic induced oxidative stress in albino mice by producing free radicals and lipid peroxidation where antioxidant enzymes were used as biomarkers.},
year = {2016}
}
TY - JOUR T1 - Nephrotoxic Effects of Arsenic in Albino Mice AU - Suman Sharma AU - Anjali Singh Gill AU - Zorawar Singh AU - Charanjit Kaur AU - P. Vijaya Y1 - 2016/02/23 PY - 2016 N1 - https://doi.org/10.11648/j.ajbio.s.2016040301.11 DO - 10.11648/j.ajbio.s.2016040301.11 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 1 EP - 4 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.s.2016040301.11 AB - Arsenic is an ubiquitous element in the environment. In the present study we investigated the effects of arsenic trioxide (AsIII) on lipid peroxidation and on the activity of antioxidant enzymes in the kidney of albino mice. Albino mice were divided into three groups. Group I were kept as control. Group II were administrated an oral dose of arsenic trioxide (3mg/kg b.w.). Group III were given an oral dose of arsenic trioxide (6mg/kg b.w.). They were acclimatized for 15 days before administration of arsenic trioxide. The autopsies were done from all the groups at 15 days post-treatment. Malondialdehyde (MDA) and activities of Superoxide dismutase (SOD) and Catalase (CAT) were analyzed in kidney of albino mice. The results showed a significant increase in concentration of MDA (p<0.05). Activities of SOD and CAT were found to decrease significantly (p<0.05). The results indicated that arsenic induced oxidative stress in albino mice by producing free radicals and lipid peroxidation where antioxidant enzymes were used as biomarkers. VL - 4 IS - 3-1 ER -
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