Background: mussaenda roxburghii hook. Belongs to family rubiaceae, is a perennial shrub moist area of valley and grows in the foothills. Objective: the present investigation was carried out to phytochemicals and pharmacological activity such anti-inflammatory, cardioprotective properties of methanolic crude extract & its fractions such as dcm extract (fraction 1), ethyl acetate extract (fraction2). Materials and methods: residual methanolic extract (fraction 3) of mussaenda roxburghii leaves which were obtained by solvent-solvent extraction process from crude methanolic extract of mussaenda roxburghii. Anti-inflammatory activity was measured by observing the mean inhibition of protein denaturation. Cardioprotective activity was evaluated by thrombolytic assay. Phytochemical screenings have done by using usual procedures. Results: an ex-vivo anti-inflammatory test demonstrated that; mean inhibition of protein denaturation 0f 1000/kg of crude methanolic extract of leave of m. Roxburghii was 17.399%. Cardioprotective properties of different extracts of m. Roxburghii was demonstrated which revealed that after treatment of clot with mother methanolic extract, dcm extract (fraction 1), ethyl acetate extract (fraction 2), residual methanolic extract (fraction3) of leaves and methanolic extract of root % clot lysis was 30.56%,27.61%,46.35%,26.02%,49.90 % respectively. Different tests with crude extracts showed that different types of alkaloids, carbohydrates, tannins were present in the leaves of m. Roxburghii. Conclusion: in these investigations demonstrates that different extracts of m. Roxburghii has significant pharmacological activities.
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American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5-1)
This article belongs to the Special Issue Herbal Remedies as Alternative to Future Drugs Development and Treatment |
| DOI | 10.11648/j.ajcem.s.2015030501.11 |
| Page(s) | 1-6 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2015. Published by Science Publishing Group |
Ex-vivo Anti-inflammatory, Cardioprotective Properties, Phytochemicals Investigation, Mean Inhibition of Protein Denaturation
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APA Style
Farzana Akther Sumi, Biswajit Sikder, Prawej Ansari, Md. Reyad-ul- Ferdous, Anaytulla, et al. (2015). Potential Ex-vivo Anti-inflammatory, Cardioprotective Properties and Phytochemical Properties of Leaves of Mussaenda Roxburghii Hook. American Journal of Clinical and Experimental Medicine, 3(5-1), 1-6. https://doi.org/10.11648/j.ajcem.s.2015030501.11
ACS Style
Farzana Akther Sumi; Biswajit Sikder; Prawej Ansari; Md. Reyad-ul- Ferdous; Anaytulla, et al. Potential Ex-vivo Anti-inflammatory, Cardioprotective Properties and Phytochemical Properties of Leaves of Mussaenda Roxburghii Hook. Am. J. Clin. Exp. Med. 2015, 3(5-1), 1-6. doi: 10.11648/j.ajcem.s.2015030501.11
AMA Style
Farzana Akther Sumi, Biswajit Sikder, Prawej Ansari, Md. Reyad-ul- Ferdous, Anaytulla, et al. Potential Ex-vivo Anti-inflammatory, Cardioprotective Properties and Phytochemical Properties of Leaves of Mussaenda Roxburghii Hook. Am J Clin Exp Med. 2015;3(5-1):1-6. doi: 10.11648/j.ajcem.s.2015030501.11
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Download@article{10.11648/j.ajcem.s.2015030501.11,
author = {Farzana Akther Sumi and Biswajit Sikder and Prawej Ansari and Md. Reyad-ul- Ferdous and Anaytulla and Mustafe Khalid Mohamed and Md. Mustarek Uddin Meemo},
title = {Potential Ex-vivo Anti-inflammatory, Cardioprotective Properties and Phytochemical Properties of Leaves of Mussaenda Roxburghii Hook},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {5-1},
pages = {1-6},
doi = {10.11648/j.ajcem.s.2015030501.11},
url = {https://doi.org/10.11648/j.ajcem.s.2015030501.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.s.2015030501.11},
abstract = {Background: mussaenda roxburghii hook. Belongs to family rubiaceae, is a perennial shrub moist area of valley and grows in the foothills. Objective: the present investigation was carried out to phytochemicals and pharmacological activity such anti-inflammatory, cardioprotective properties of methanolic crude extract & its fractions such as dcm extract (fraction 1), ethyl acetate extract (fraction2). Materials and methods: residual methanolic extract (fraction 3) of mussaenda roxburghii leaves which were obtained by solvent-solvent extraction process from crude methanolic extract of mussaenda roxburghii. Anti-inflammatory activity was measured by observing the mean inhibition of protein denaturation. Cardioprotective activity was evaluated by thrombolytic assay. Phytochemical screenings have done by using usual procedures. Results: an ex-vivo anti-inflammatory test demonstrated that; mean inhibition of protein denaturation 0f 1000/kg of crude methanolic extract of leave of m. Roxburghii was 17.399%. Cardioprotective properties of different extracts of m. Roxburghii was demonstrated which revealed that after treatment of clot with mother methanolic extract, dcm extract (fraction 1), ethyl acetate extract (fraction 2), residual methanolic extract (fraction3) of leaves and methanolic extract of root % clot lysis was 30.56%,27.61%,46.35%,26.02%,49.90 % respectively. Different tests with crude extracts showed that different types of alkaloids, carbohydrates, tannins were present in the leaves of m. Roxburghii. Conclusion: in these investigations demonstrates that different extracts of m. Roxburghii has significant pharmacological activities.},
year = {2015}
}
TY - JOUR T1 - Potential Ex-vivo Anti-inflammatory, Cardioprotective Properties and Phytochemical Properties of Leaves of Mussaenda Roxburghii Hook AU - Farzana Akther Sumi AU - Biswajit Sikder AU - Prawej Ansari AU - Md. Reyad-ul- Ferdous AU - Anaytulla AU - Mustafe Khalid Mohamed AU - Md. Mustarek Uddin Meemo Y1 - 2015/07/15 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.s.2015030501.11 DO - 10.11648/j.ajcem.s.2015030501.11 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 1 EP - 6 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.s.2015030501.11 AB - Background: mussaenda roxburghii hook. Belongs to family rubiaceae, is a perennial shrub moist area of valley and grows in the foothills. Objective: the present investigation was carried out to phytochemicals and pharmacological activity such anti-inflammatory, cardioprotective properties of methanolic crude extract & its fractions such as dcm extract (fraction 1), ethyl acetate extract (fraction2). Materials and methods: residual methanolic extract (fraction 3) of mussaenda roxburghii leaves which were obtained by solvent-solvent extraction process from crude methanolic extract of mussaenda roxburghii. Anti-inflammatory activity was measured by observing the mean inhibition of protein denaturation. Cardioprotective activity was evaluated by thrombolytic assay. Phytochemical screenings have done by using usual procedures. Results: an ex-vivo anti-inflammatory test demonstrated that; mean inhibition of protein denaturation 0f 1000/kg of crude methanolic extract of leave of m. Roxburghii was 17.399%. Cardioprotective properties of different extracts of m. Roxburghii was demonstrated which revealed that after treatment of clot with mother methanolic extract, dcm extract (fraction 1), ethyl acetate extract (fraction 2), residual methanolic extract (fraction3) of leaves and methanolic extract of root % clot lysis was 30.56%,27.61%,46.35%,26.02%,49.90 % respectively. Different tests with crude extracts showed that different types of alkaloids, carbohydrates, tannins were present in the leaves of m. Roxburghii. Conclusion: in these investigations demonstrates that different extracts of m. Roxburghii has significant pharmacological activities. VL - 3 IS - 5-1 ER -
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