Introduction This study describes the impact of a daily sublingual Probelte Pharma autovaccine ® program to prevent recurrent symptomatic UTI in non-responders adults to conventional antibiotic prophylaxis. Material and Methods Observational prospective open study including patients with recurrent UTI. A sublingual vaccine containing ethanol-killed bacteria extract from specific patient´s uropathogenic strains were prepared from patient´s semen or urine sample . The main outcome criteria were the number and severity of symptomatic/clinical UTI, specific antibiotic dosage and duration of use, adverse effects if any, and necessity to stop or change the antibiotic was noted. Results Thirty-two patients met inclusion/exclusion criteria (17 men, 53.1%; 15 women, 46.8%).After 10 years follow up under autovaccine, the number of positive urine cultures decreased from 100% to 87% (P >0.05) and no patient take any curative antibiotics. Conclusion Probelte Pharma autovaccine ® provides a reduction in symptomatic repeated UTI and descrease the use of antibiotics with a good tolerance.
| Published in |
American Journal of Life Sciences (Volume 2, Issue 6-3)
This article belongs to the Special Issue Microbiology Research |
| DOI | 10.11648/j.ajls.s.2014020603.13 |
| Page(s) | 13-17 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Chronic Urinary Tract Infections, Vaccine, Sublingual, Treatment
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APA Style
Gallego-Vilar Daniel, Sanchis-Verdu Laura, Beltran Persiva Jose, Cuñat-Albert Enrique, Cervello-Grima Enrique, et al. (2014). Autovaccines for Chronic Urinary Tract Infections; Ten Years Follow-Up Experience. American Journal of Life Sciences, 2(6-3), 13-17. https://doi.org/10.11648/j.ajls.s.2014020603.13
ACS Style
Gallego-Vilar Daniel; Sanchis-Verdu Laura; Beltran Persiva Jose; Cuñat-Albert Enrique; Cervello-Grima Enrique, et al. Autovaccines for Chronic Urinary Tract Infections; Ten Years Follow-Up Experience. Am. J. Life Sci. 2014, 2(6-3), 13-17. doi: 10.11648/j.ajls.s.2014020603.13
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Download@article{10.11648/j.ajls.s.2014020603.13,
author = {Gallego-Vilar Daniel and Sanchis-Verdu Laura and Beltran Persiva Jose and Cuñat-Albert Enrique and Cervello-Grima Enrique and Gallego-Gomez Juan and Perez-Mestre Mateo},
title = {Autovaccines for Chronic Urinary Tract Infections; Ten Years Follow-Up Experience},
journal = {American Journal of Life Sciences},
volume = {2},
number = {6-3},
pages = {13-17},
doi = {10.11648/j.ajls.s.2014020603.13},
url = {https://doi.org/10.11648/j.ajls.s.2014020603.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2014020603.13},
abstract = {Introduction This study describes the impact of a daily sublingual Probelte Pharma autovaccine ® program to prevent recurrent symptomatic UTI in non-responders adults to conventional antibiotic prophylaxis. Material and Methods Observational prospective open study including patients with recurrent UTI. A sublingual vaccine containing ethanol-killed bacteria extract from specific patient´s uropathogenic strains were prepared from patient´s semen or urine sample . The main outcome criteria were the number and severity of symptomatic/clinical UTI, specific antibiotic dosage and duration of use, adverse effects if any, and necessity to stop or change the antibiotic was noted. Results Thirty-two patients met inclusion/exclusion criteria (17 men, 53.1%; 15 women, 46.8%).After 10 years follow up under autovaccine, the number of positive urine cultures decreased from 100% to 87% (P >0.05) and no patient take any curative antibiotics. Conclusion Probelte Pharma autovaccine ® provides a reduction in symptomatic repeated UTI and descrease the use of antibiotics with a good tolerance.},
year = {2014}
}
TY - JOUR T1 - Autovaccines for Chronic Urinary Tract Infections; Ten Years Follow-Up Experience AU - Gallego-Vilar Daniel AU - Sanchis-Verdu Laura AU - Beltran Persiva Jose AU - Cuñat-Albert Enrique AU - Cervello-Grima Enrique AU - Gallego-Gomez Juan AU - Perez-Mestre Mateo Y1 - 2014/11/24 PY - 2014 N1 - https://doi.org/10.11648/j.ajls.s.2014020603.13 DO - 10.11648/j.ajls.s.2014020603.13 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 13 EP - 17 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2014020603.13 AB - Introduction This study describes the impact of a daily sublingual Probelte Pharma autovaccine ® program to prevent recurrent symptomatic UTI in non-responders adults to conventional antibiotic prophylaxis. Material and Methods Observational prospective open study including patients with recurrent UTI. A sublingual vaccine containing ethanol-killed bacteria extract from specific patient´s uropathogenic strains were prepared from patient´s semen or urine sample . The main outcome criteria were the number and severity of symptomatic/clinical UTI, specific antibiotic dosage and duration of use, adverse effects if any, and necessity to stop or change the antibiotic was noted. Results Thirty-two patients met inclusion/exclusion criteria (17 men, 53.1%; 15 women, 46.8%).After 10 years follow up under autovaccine, the number of positive urine cultures decreased from 100% to 87% (P >0.05) and no patient take any curative antibiotics. Conclusion Probelte Pharma autovaccine ® provides a reduction in symptomatic repeated UTI and descrease the use of antibiotics with a good tolerance. VL - 2 IS - 6-3 ER -
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