Retinal Structural Changes in Patients with Mild Cognitive Impairment

Demirtzoglou Iordanis; Tsolaki Magda; Gougoulias Kyriakos; Oikonomidis Panagiotis; Karampatakis Vasileios

doi:doi:10.11648/j.cmr.s.2015040201.11

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Retinal Structural Changes in Patients with Mild Cognitive Impairment

Demirtzoglou Iordanis, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis, Karampatakis Vasileios

Published in Clinical Medicine Research (Volume 4, Issue 2-1)

Received: 30 July 2014 Accepted: 22 August 2014 Published: 17 September 2014

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Abstract

Purpose: To assess retinal structural changes in persons with mild cognitive impairment (MCI) and to correlate these changes with the level of cognitive function. Material-methods: Using high-resolution spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness loss, macular volume and macular thickness loss in all nine EDTRS (early treatment diabetic retinopathy study) areas, and macular Ganglion Cell Complex (GCC) (inner plexiform + ganglion cell layer + retinal nerve fiber) thickness loss. We assessed cognitive function using Mini Mental State Examination (MMSE) score. Results: In the study group there was found a statistically significant decrease in RNFL overall (Mann-Whitney test, p: 0.009) and temporal thickness (T-test, p: 0.013) and increased macular GCC Focal Volume Loss (FVL%) (Mann-Whitney test, p: 0.001) compared to the control group. In control group was also found a statistically significant positive correlation between retinal structural parameters and MMSE score. Conclusion: Our preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls. GCC FVL% is significantly increased in patients with MCI compared to normal controls suggesting that there is macular focal loss of ganglion cells in MCI patients.

Published in	Clinical Medicine Research (Volume 4, Issue 2-1) This article belongs to the Special Issue Recent Research in Dementia
DOI	10.11648/j.cmr.s.2015040201.11
Page(s)	1-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Mild Cognitive Impairment, Mini Mental State Examination, Optical Coherence Tomography

References

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APA Style

Demirtzoglou Iordanis, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis, Karampatakis Vasileios. (2014). Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clinical Medicine Research, 4(2-1), 1-7. https://doi.org/10.11648/j.cmr.s.2015040201.11

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ACS Style

Demirtzoglou Iordanis; Tsolaki Magda; Gougoulias Kyriakos; Oikonomidis Panagiotis; Karampatakis Vasileios. Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clin. Med. Res. 2014, 4(2-1), 1-7. doi: 10.11648/j.cmr.s.2015040201.11

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AMA Style

Demirtzoglou Iordanis, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis, Karampatakis Vasileios. Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clin Med Res. 2014;4(2-1):1-7. doi: 10.11648/j.cmr.s.2015040201.11

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@article{10.11648/j.cmr.s.2015040201.11,
  author = {Demirtzoglou Iordanis and Tsolaki Magda and Gougoulias Kyriakos and Oikonomidis Panagiotis and Karampatakis Vasileios},
  title = {Retinal Structural Changes in Patients with Mild Cognitive Impairment},
  journal = {Clinical Medicine Research},
  volume = {4},
  number = {2-1},
  pages = {1-7},
  doi = {10.11648/j.cmr.s.2015040201.11},
  url = {https://doi.org/10.11648/j.cmr.s.2015040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.s.2015040201.11},
  abstract = {Purpose: To assess retinal structural changes in persons with mild cognitive impairment (MCI) and to correlate these changes with the level of cognitive function. Material-methods: Using high-resolution spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness loss, macular volume and macular thickness loss in all nine EDTRS (early treatment diabetic retinopathy study) areas, and macular Ganglion Cell Complex (GCC) (inner plexiform + ganglion cell layer + retinal nerve fiber) thickness loss. We assessed cognitive function using Mini Mental State Examination (MMSE) score. Results: In the study group there was found a statistically significant decrease in RNFL overall (Mann-Whitney test, p: 0.009) and temporal thickness (T-test, p: 0.013) and increased macular GCC Focal Volume Loss (FVL%) (Mann-Whitney test, p: 0.001) compared to the control group. In control group was also found a statistically significant positive correlation between retinal structural parameters and MMSE score. Conclusion: Our preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls. GCC FVL% is significantly increased in patients with MCI compared to normal controls suggesting that there is macular focal loss of ganglion cells in MCI patients.},
 year = {2014}
}

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TY  - JOUR
T1  - Retinal Structural Changes in Patients with Mild Cognitive Impairment
AU  - Demirtzoglou Iordanis
AU  - Tsolaki Magda
AU  - Gougoulias Kyriakos
AU  - Oikonomidis Panagiotis
AU  - Karampatakis Vasileios
Y1  - 2014/09/17
PY  - 2014
N1  - https://doi.org/10.11648/j.cmr.s.2015040201.11
DO  - 10.11648/j.cmr.s.2015040201.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.s.2015040201.11
AB  - Purpose: To assess retinal structural changes in persons with mild cognitive impairment (MCI) and to correlate these changes with the level of cognitive function. Material-methods: Using high-resolution spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness loss, macular volume and macular thickness loss in all nine EDTRS (early treatment diabetic retinopathy study) areas, and macular Ganglion Cell Complex (GCC) (inner plexiform + ganglion cell layer + retinal nerve fiber) thickness loss. We assessed cognitive function using Mini Mental State Examination (MMSE) score. Results: In the study group there was found a statistically significant decrease in RNFL overall (Mann-Whitney test, p: 0.009) and temporal thickness (T-test, p: 0.013) and increased macular GCC Focal Volume Loss (FVL%) (Mann-Whitney test, p: 0.001) compared to the control group. In control group was also found a statistically significant positive correlation between retinal structural parameters and MMSE score. Conclusion: Our preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls. GCC FVL% is significantly increased in patients with MCI compared to normal controls suggesting that there is macular focal loss of ganglion cells in MCI patients.
VL  - 4
IS  - 2-1
ER  -

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Author Information

Demirtzoglou Iordanis

Fellow of European Board of Ophthalmology, Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Tsolaki Magda

Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Gougoulias Kyriakos

Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece
Oikonomidis Panagiotis

Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Karampatakis Vasileios

Director of Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece

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APA Style

Demirtzoglou Iordanis, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis, Karampatakis Vasileios. (2014). Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clinical Medicine Research, 4(2-1), 1-7. https://doi.org/10.11648/j.cmr.s.2015040201.11

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ACS Style

Demirtzoglou Iordanis; Tsolaki Magda; Gougoulias Kyriakos; Oikonomidis Panagiotis; Karampatakis Vasileios. Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clin. Med. Res. 2014, 4(2-1), 1-7. doi: 10.11648/j.cmr.s.2015040201.11

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AMA Style

Demirtzoglou Iordanis, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis, Karampatakis Vasileios. Retinal Structural Changes in Patients with Mild Cognitive Impairment. Clin Med Res. 2014;4(2-1):1-7. doi: 10.11648/j.cmr.s.2015040201.11

Copy | Download

@article{10.11648/j.cmr.s.2015040201.11,
  author = {Demirtzoglou Iordanis and Tsolaki Magda and Gougoulias Kyriakos and Oikonomidis Panagiotis and Karampatakis Vasileios},
  title = {Retinal Structural Changes in Patients with Mild Cognitive Impairment},
  journal = {Clinical Medicine Research},
  volume = {4},
  number = {2-1},
  pages = {1-7},
  doi = {10.11648/j.cmr.s.2015040201.11},
  url = {https://doi.org/10.11648/j.cmr.s.2015040201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.s.2015040201.11},
  abstract = {Purpose: To assess retinal structural changes in persons with mild cognitive impairment (MCI) and to correlate these changes with the level of cognitive function. Material-methods: Using high-resolution spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness loss, macular volume and macular thickness loss in all nine EDTRS (early treatment diabetic retinopathy study) areas, and macular Ganglion Cell Complex (GCC) (inner plexiform + ganglion cell layer + retinal nerve fiber) thickness loss. We assessed cognitive function using Mini Mental State Examination (MMSE) score. Results: In the study group there was found a statistically significant decrease in RNFL overall (Mann-Whitney test, p: 0.009) and temporal thickness (T-test, p: 0.013) and increased macular GCC Focal Volume Loss (FVL%) (Mann-Whitney test, p: 0.001) compared to the control group. In control group was also found a statistically significant positive correlation between retinal structural parameters and MMSE score. Conclusion: Our preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls. GCC FVL% is significantly increased in patients with MCI compared to normal controls suggesting that there is macular focal loss of ganglion cells in MCI patients.},
 year = {2014}
}

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TY  - JOUR
T1  - Retinal Structural Changes in Patients with Mild Cognitive Impairment
AU  - Demirtzoglou Iordanis
AU  - Tsolaki Magda
AU  - Gougoulias Kyriakos
AU  - Oikonomidis Panagiotis
AU  - Karampatakis Vasileios
Y1  - 2014/09/17
PY  - 2014
N1  - https://doi.org/10.11648/j.cmr.s.2015040201.11
DO  - 10.11648/j.cmr.s.2015040201.11
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 1
EP  - 7
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.s.2015040201.11
AB  - Purpose: To assess retinal structural changes in persons with mild cognitive impairment (MCI) and to correlate these changes with the level of cognitive function. Material-methods: Using high-resolution spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness loss, macular volume and macular thickness loss in all nine EDTRS (early treatment diabetic retinopathy study) areas, and macular Ganglion Cell Complex (GCC) (inner plexiform + ganglion cell layer + retinal nerve fiber) thickness loss. We assessed cognitive function using Mini Mental State Examination (MMSE) score. Results: In the study group there was found a statistically significant decrease in RNFL overall (Mann-Whitney test, p: 0.009) and temporal thickness (T-test, p: 0.013) and increased macular GCC Focal Volume Loss (FVL%) (Mann-Whitney test, p: 0.001) compared to the control group. In control group was also found a statistically significant positive correlation between retinal structural parameters and MMSE score. Conclusion: Our preliminary study results suggest that RNFL overall and temporal thickness in patients with MCI is significantly decreased compared to normal controls. GCC FVL% is significantly increased in patients with MCI compared to normal controls suggesting that there is macular focal loss of ganglion cells in MCI patients.
VL  - 4
IS  - 2-1
ER  -

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