A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme

Bouchentouf Salim; Ghalem Said; Missoum Noureddine; Allali Hocine; Bouchentouf Amina Angelika

doi:doi:10.11648/j.ijctc.20170501.12

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A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme

Bouchentouf Salim, Ghalem Said, Missoum Noureddine, Allali Hocine, Bouchentouf Amina Angelika

Published in International Journal of Computational and Theoretical Chemistry (Volume 5, Issue 1)

Received: 24 February 2017 Accepted: 20 March 2017 Published: 13 April 2017

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Abstract

Clove (Syzygium aromaticum) is precious spice used over the world in cuisine and medical treatment. Essential clove oil contains many bioactive molecules which have therapeutic interest. In this work we study interactions of DPP-4 enzyme (responsible of diabetes type 2) with main molecules contained in clove essential oil using molecular mechanic, molecular dynamics and molecular docking (method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex). Molecular Operating Environment software was used. The obtained results show that Acetyleugenol molecule is the best inhibitor of DPP-4 enzyme according to score energy. As a conclusion we can say that clove has a significant influence on diabetes treatment.

Published in	International Journal of Computational and Theoretical Chemistry (Volume 5, Issue 1)
DOI	10.11648/j.ijctc.20170501.12
Page(s)	9-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Diabetes Type 2 (T2DM), Clove, DPP-4, MOE (Molecular Operating Environment)

References

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APA Style

Bouchentouf Salim, Ghalem Said, Missoum Noureddine, Allali Hocine, Bouchentouf Amina Angelika. (2017). A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. International Journal of Computational and Theoretical Chemistry, 5(1), 9-13. https://doi.org/10.11648/j.ijctc.20170501.12

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ACS Style

Bouchentouf Salim; Ghalem Said; Missoum Noureddine; Allali Hocine; Bouchentouf Amina Angelika. A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. Int. J. Comput. Theor. Chem. 2017, 5(1), 9-13. doi: 10.11648/j.ijctc.20170501.12

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AMA Style

Bouchentouf Salim, Ghalem Said, Missoum Noureddine, Allali Hocine, Bouchentouf Amina Angelika. A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. Int J Comput Theor Chem. 2017;5(1):9-13. doi: 10.11648/j.ijctc.20170501.12

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@article{10.11648/j.ijctc.20170501.12,
  author = {Bouchentouf Salim and Ghalem Said and Missoum Noureddine and Allali Hocine and Bouchentouf Amina Angelika},
  title = {A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme},
  journal = {International Journal of Computational and Theoretical Chemistry},
  volume = {5},
  number = {1},
  pages = {9-13},
  doi = {10.11648/j.ijctc.20170501.12},
  url = {https://doi.org/10.11648/j.ijctc.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijctc.20170501.12},
  abstract = {Clove (Syzygium aromaticum) is precious spice used over the world in cuisine and medical treatment. Essential clove oil contains many bioactive molecules which have therapeutic interest. In this work we study interactions of DPP-4 enzyme (responsible of diabetes type 2) with main molecules contained in clove essential oil using molecular mechanic, molecular dynamics and molecular docking (method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex). Molecular Operating Environment software was used. The obtained results show that Acetyleugenol molecule is the best inhibitor of DPP-4 enzyme according to score energy. As a conclusion we can say that clove has a significant influence on diabetes treatment.},
 year = {2017}
}

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TY  - JOUR
T1  - A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme
AU  - Bouchentouf Salim
AU  - Ghalem Said
AU  - Missoum Noureddine
AU  - Allali Hocine
AU  - Bouchentouf Amina Angelika
Y1  - 2017/04/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijctc.20170501.12
DO  - 10.11648/j.ijctc.20170501.12
T2  - International Journal of Computational and Theoretical Chemistry
JF  - International Journal of Computational and Theoretical Chemistry
JO  - International Journal of Computational and Theoretical Chemistry
SP  - 9
EP  - 13
PB  - Science Publishing Group
SN  - 2376-7308
UR  - https://doi.org/10.11648/j.ijctc.20170501.12
AB  - Clove (Syzygium aromaticum) is precious spice used over the world in cuisine and medical treatment. Essential clove oil contains many bioactive molecules which have therapeutic interest. In this work we study interactions of DPP-4 enzyme (responsible of diabetes type 2) with main molecules contained in clove essential oil using molecular mechanic, molecular dynamics and molecular docking (method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex). Molecular Operating Environment software was used. The obtained results show that Acetyleugenol molecule is the best inhibitor of DPP-4 enzyme according to score energy. As a conclusion we can say that clove has a significant influence on diabetes treatment.
VL  - 5
IS  - 1
ER  -

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Author Information

Bouchentouf Salim

Faculty of Technology, Doctor Tahar Moulay University, Saida, Algeria
Ghalem Said

Laboratory of Naturals Products and Bioactives, Tlemcen, Algeria
Missoum Noureddine

Laboratory of Naturals Products and Bioactives, Tlemcen, Algeria
Allali Hocine

Laboratory of Naturals Products and Bioactives, Tlemcen, Algeria
Bouchentouf Amina Angelika

Department of Mathematics, Faculty of Sciences, Djillali Liabes University, Sidi Bel Abbes, Algeria

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Plain Text BibTeX RIS

APA Style

Bouchentouf Salim, Ghalem Said, Missoum Noureddine, Allali Hocine, Bouchentouf Amina Angelika. (2017). A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. International Journal of Computational and Theoretical Chemistry, 5(1), 9-13. https://doi.org/10.11648/j.ijctc.20170501.12

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ACS Style

Bouchentouf Salim; Ghalem Said; Missoum Noureddine; Allali Hocine; Bouchentouf Amina Angelika. A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. Int. J. Comput. Theor. Chem. 2017, 5(1), 9-13. doi: 10.11648/j.ijctc.20170501.12

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AMA Style

Bouchentouf Salim, Ghalem Said, Missoum Noureddine, Allali Hocine, Bouchentouf Amina Angelika. A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme. Int J Comput Theor Chem. 2017;5(1):9-13. doi: 10.11648/j.ijctc.20170501.12

Copy | Download

@article{10.11648/j.ijctc.20170501.12,
  author = {Bouchentouf Salim and Ghalem Said and Missoum Noureddine and Allali Hocine and Bouchentouf Amina Angelika},
  title = {A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme},
  journal = {International Journal of Computational and Theoretical Chemistry},
  volume = {5},
  number = {1},
  pages = {9-13},
  doi = {10.11648/j.ijctc.20170501.12},
  url = {https://doi.org/10.11648/j.ijctc.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijctc.20170501.12},
  abstract = {Clove (Syzygium aromaticum) is precious spice used over the world in cuisine and medical treatment. Essential clove oil contains many bioactive molecules which have therapeutic interest. In this work we study interactions of DPP-4 enzyme (responsible of diabetes type 2) with main molecules contained in clove essential oil using molecular mechanic, molecular dynamics and molecular docking (method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex). Molecular Operating Environment software was used. The obtained results show that Acetyleugenol molecule is the best inhibitor of DPP-4 enzyme according to score energy. As a conclusion we can say that clove has a significant influence on diabetes treatment.},
 year = {2017}
}

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TY  - JOUR
T1  - A Note Study on Antidiabetic Effect of Main Molecules Contained in Clove Using Molecular Modeling Interactions with DPP-4 Enzyme
AU  - Bouchentouf Salim
AU  - Ghalem Said
AU  - Missoum Noureddine
AU  - Allali Hocine
AU  - Bouchentouf Amina Angelika
Y1  - 2017/04/13
PY  - 2017
N1  - https://doi.org/10.11648/j.ijctc.20170501.12
DO  - 10.11648/j.ijctc.20170501.12
T2  - International Journal of Computational and Theoretical Chemistry
JF  - International Journal of Computational and Theoretical Chemistry
JO  - International Journal of Computational and Theoretical Chemistry
SP  - 9
EP  - 13
PB  - Science Publishing Group
SN  - 2376-7308
UR  - https://doi.org/10.11648/j.ijctc.20170501.12
AB  - Clove (Syzygium aromaticum) is precious spice used over the world in cuisine and medical treatment. Essential clove oil contains many bioactive molecules which have therapeutic interest. In this work we study interactions of DPP-4 enzyme (responsible of diabetes type 2) with main molecules contained in clove essential oil using molecular mechanic, molecular dynamics and molecular docking (method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex). Molecular Operating Environment software was used. The obtained results show that Acetyleugenol molecule is the best inhibitor of DPP-4 enzyme according to score energy. As a conclusion we can say that clove has a significant influence on diabetes treatment.
VL  - 5
IS  - 1
ER  -

Copy | Download