We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients.
| Published in | Journal of Surgery (Volume 3, Issue 6) |
| DOI | 10.11648/j.js.20150306.14 |
| Page(s) | 71-76 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Rectal Cancer, Negative LN, Survival
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APA Style
Amir A. Fikry, Niveen A. Abo-Touk. (2015). Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. Journal of Surgery, 3(6), 71-76. https://doi.org/10.11648/j.js.20150306.14
ACS Style
Amir A. Fikry; Niveen A. Abo-Touk. Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. J. Surg. 2015, 3(6), 71-76. doi: 10.11648/j.js.20150306.14
AMA Style
Amir A. Fikry, Niveen A. Abo-Touk. Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma. J Surg. 2015;3(6):71-76. doi: 10.11648/j.js.20150306.14
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Download@article{10.11648/j.js.20150306.14,
author = {Amir A. Fikry and Niveen A. Abo-Touk},
title = {Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma},
journal = {Journal of Surgery},
volume = {3},
number = {6},
pages = {71-76},
doi = {10.11648/j.js.20150306.14},
url = {https://doi.org/10.11648/j.js.20150306.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150306.14},
abstract = {We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients.},
year = {2015}
}
TY - JOUR T1 - Prognostic Value of Negative Lymph Nodes (NLN) in Rectal Adenocarcinoma AU - Amir A. Fikry AU - Niveen A. Abo-Touk Y1 - 2015/12/10 PY - 2015 N1 - https://doi.org/10.11648/j.js.20150306.14 DO - 10.11648/j.js.20150306.14 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 71 EP - 76 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20150306.14 AB - We studied the impact on prognosis by negative LN (NLN) harvest count on rectal cancer patients, using immunohistochemistry to exclude micrometastasis in nodes negative by hematoxylin and eosin (H & E) stain. A prospective study including 114 patients in Mansoura university hospitals between 2005-2008 aged 18 years or older who were diagnosed as having localized invasive adenocarcinoma rectum with stage I, II & III was conducted. Close follow up done in both surgery department and department of clinical oncology and nuclear medicine for 5 years. We examined patient survival in relation to the negative lymph node count. Our results revealed that the number of negative lymph nodes could affect significantly survival curves where the disease free survival and overall survival were significantly better among the group of patients with more than ten negative LNs (P=0.021 & 0.012 respectively). In conclusion, the negative lymph node count is associated with improved survival of rectal cancer patients. VL - 3 IS - 6 ER -
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